Hyper-activation of Notch3 amplifies the proliferative potential of rhabdomyosarcoma cells.
Rhabdomyosarcoma Peg Box (RMS) is a pediatric myogenic-derived soft tissue sarcoma that includes two major histopathological subtypes: embryonal and alveolar.The majority of alveolar RMS expresses PAX3-FOXO1 fusion oncoprotein, associated with the worst prognosis.RMS cells show myogenic markers expression but are unable to terminally differentiate.